Natural history of left ventricular hypertrophy in infants of diabetic mothers

Abstract Background Left ventricular hypertrophy (LVH) in infants of diabetic mothers (IDMs) has been generally considered a benign condition, which usually regresses as the stimulus for insulin production disappears, resulting normalized left wall thickness 6 months life. However, these conclusions have based on small, mostly outdated cohort studies. Indeed, it recently shown that increased mass persists late infancy (6 to 12 months), long after intrauterine exposure removed, suggesting other factors may potentially contribute. Purpose This study sought describe characteristics and natural course LVH well-characterized consecutive IDMs. Methods Sixty IDMs with retrospectively identified enrolled study. All were evaluated at baseline every until LV regression, defined decrease measurement into normal reference range cardiac parameters (z-score >−2 <2). A comprehensive assessment was performed those patients diagnostic markers suggestive different cause and/or without significant reduction during follow-up. Results At 1-year follow-up, all showed maximal (MWT) (MWT-mm: 6.67±2.37 vs. 5.83±1.70, p-value<0.001; MWT-z-score: 6.67±4.71 2.39±2.55, p-value<0.001) outflow tract (LVOT) gradient (15.35±15.58 11.22±8.14, p-value<0.004), compared baseline, regression or residual mild moderate (57%, 28%, 12%, respectively) (Figure 1), except 2 persistent severe LVH, clinical-genetic diagnosed Noonan syndrome multiple lentigines. multivariate analysis, MWT significantly associated follow-up OR 0.48 [0.29–0.79], p-value=0.004; 0.71 [0.56–0.90], p-value=0.004) an inversely proportional fashion. Overall, 59%, 72% 79% complete 1-year, 2-year 3-year respectively 2). Excluding two first years Conclusions represents condition In combined clinical specific disease, work-up is required definite diagnosis. FUNDunding Acknowledgement Type funding sources: None. Figure 1